Azo compounds, or aniline dyes, have a broad spectrum of antimicrobial activity. This has led to their widespread use in agriculture to protect crops, as well as in industrial processes and technologies to protect various materials (plastics, wood, rubber, etc.) from microbial attack. At the same time, the use of azo dyes in medicine is limited by their high toxicity and potential carcinogenicity. Resistance to azo dyes develops extremely slowly in clinical strains of bacteria and fungi due to their limited exposure to these compounds. Consequently, the sensitivity values of microbial cultures to azo dyes will remain stable over a long period of time. It has been established that strains of the same species are characterized by marked heterogeneity in their sensitivity to azo dyes. These stable characteristics of bacterial and fungal strains are required for conducting epidemiological analysis, using them as phenotypic epidemiological markers. Repeated isolation of cultures with similar indicators from objects in the nosocomial environment can be regarded as evidence of microorganisms’ circulation in the nosocomial environment, which is considered one of the main signs of nosocomial (hospital) strains.
Yuri N. Maslov – Doctor of Medical Sciences, Professor, Perm, Russia.
Anton Yu. Ponomarev – Candidate of Candidate of Medical Sciences, Associate Professor, Perm, Russia.
Aleksey Yu. Maslov – West Medica Produktions- und Handels- GmbH, Wiener Neudorf, Austria.
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