The lecture addresses issues related to the cytological diagnosis of pathological changes in the glandular epithelium of the uterine cervix. The cytological criteria for the categories AGC-NOS (atypical glandular cells, not otherwise specified), AGC-FN (atypical glandular cells, favor neoplasia), AIS (adenocarcinoma in situ), and invasive adenocarcinoma of the endocervix and endometrium are described. For each category, key cytological characteristics are described, including group architecture, nuclear features, cytoplasmic features, and background characteristics. The diagnosis of glandular epithelial lesions remains a challenging task requiring a high level of cytological expertise. Improvement in diagnostic accuracy can be achieved through the use of liquid-based cytology, adherence to the standardized Bethesda System, continuous professional development, and the implementation of new technologies.
Karine T. Kasoyan – Associate Professor of the Department of Clinical Laboratory Diagnostics with a course in Laboratory Immunology at Federal State Budgetary Educational Institution of Further Professional Education ‘Russian Medical Academy of Postgraduate Education’ of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
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DOI: 10.14489/lcmp.2026.01.pp.017-025
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