Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

ISSN 2712-9330 (Online)

  • Continuous numbering: 19
  • Pages: 36-40
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Heading: Clinical Case

Loose Anagen Hair Syndrome (LAHS) is a rare form of non-scarring alopecia characterized by disruption of hair shaft anchorage in the follicle during the anagen phase. The disease is most often diagnosed in children, primarily girls. This article presents current data on the pathogenesis and diagnosis of the syndrome and describes a clinical case.
Yuliana B. Titarenko – MD, PhD, dermatovenerologist, trichologist, cosmetologist, auditor of the Moscow Regional Branch of the Interregional Public Organization of Trichologists and Hair Research Specialists ‘Professional Society of Trichologists’, Moscow, Russia.
Maria V. Khaldina – MD, PhD, dermatovenerologist, trichologist, and cosmetologist. Chairperson of the Moscow Regional Branch of the Interregional Public Organization of Trichologists and Hair Research Specialists ‘Professional Society of Trichologists’ and Chief Physician of the M.Ya. Mudrov Health Clinic, Moscow, Russia.
Elena V. Satina – dermatovenerologist, trichologist, physiotherapist, cosmetologist; Scientific Director of the Training Center at the Mudrov International Institute of Integrative Methods in Aesthetic and Anti-Aging Medicine, Moscow, Russia.
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4. Melo M, Phillippi E, Moninger T, et al. Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome. HGG Adv. 2025;6(4):100495. DOI: 10.1016/j.xhgg.2025.100495
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6. Randolph MJ, Gwillim EC, Nguyen B, Tosti A. The psychologic impact of loose anagen syndrome and short anagen syndrome. Pediatr Dermatol. 2022;39:567-9. DOI: 10.1111/pde.15002
7. Huckstadt V, Chinton J, Gomez A, et al. Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: first familial case reported. Am J Med Genet A. 2021;185(4):1256-60. DOI: 10.1002/ajmg.a.62089
8. Garcia-Garcia SC, Herz-Ruelas ME, Gomez-Flores M. Association of trichorhinophalangeal syndrome and loose anagen syndrome: a case report. Skin Appendage Disord. 2020;6(3):162-7. DOI: 10.1159/000506524

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DOI: 10.14489/lcmp.2026.01.pp.036-040
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Use the reference below to cite the publication

Titarenko YuB, Khaldina MV, Satina EV. Loose anagen hair syndrome: a case report and current insights into pathogenesis. Laboratory and Clinical Medicine. Pharmacy. 2026;6(1):36-40. (In Russ). DOI: 10.14489/lcmp. 2026.01.pp.036-040