Loose Anagen Hair Syndrome (LAHS) is a rare form of non-scarring alopecia characterized by disruption of hair shaft anchorage in the follicle during the anagen phase. The disease is most often diagnosed in children, primarily girls. This article presents current data on the pathogenesis and diagnosis of the syndrome and describes a clinical case.
Yuliana B. Titarenko – MD, PhD, dermatovenerologist, trichologist, cosmetologist, auditor of the Moscow Regional Branch of the Interregional Public Organization of Trichologists and Hair Research Specialists ‘Professional Society of Trichologists’, Moscow, Russia.
Maria V. Khaldina – MD, PhD, dermatovenerologist, trichologist, and cosmetologist. Chairperson of the Moscow Regional Branch of the Interregional Public Organization of Trichologists and Hair Research Specialists ‘Professional Society of Trichologists’ and Chief Physician of the M.Ya. Mudrov Health Clinic, Moscow, Russia.
Elena V. Satina – dermatovenerologist, trichologist, physiotherapist, cosmetologist; Scientific Director of the Training Center at the Mudrov International Institute of Integrative Methods in Aesthetic and Anti-Aging Medicine, Moscow, Russia.
1. Phillippi E, Melo M, Messingham KN, El-Shanti H. Loose anagen hair associated with wooly hair caused by a heterozygous, intronic KRT71 variant. Genes (Basel). 2025;16(4):459. DOI: 10.3390/genes16040459
2. Dhurat RP, Deshpande DJ. Loose anagen hair syndrome. Int J Trichology. 2010;2(2):96-100. DOI: 10.4103/0974-7753.77513
3. Chapalain V, Winter H, Langbein L, et al. Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. Arch Dermatol. 2002;138:501-6. DOI: 10.1001/archderm.138.4.501
4. Melo M, Phillippi E, Moninger T, et al. Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome. HGG Adv. 2025;6(4):100495. DOI: 10.1016/j.xhgg.2025.100495
5. Porter RM, Corden LD, Lunny DP, et al. Keratin K6IRS is specific to the inner root sheath of hair follicle in mice and humans. Br J Dermatol. 2001;145:558-68. DOI: 10.1046/j.1365-2133.2001.04463.x
6. Randolph MJ, Gwillim EC, Nguyen B, Tosti A. The psychologic impact of loose anagen syndrome and short anagen syndrome. Pediatr Dermatol. 2022;39:567-9. DOI: 10.1111/pde.15002
7. Huckstadt V, Chinton J, Gomez A, et al. Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: first familial case reported. Am J Med Genet A. 2021;185(4):1256-60. DOI: 10.1002/ajmg.a.62089
8. Garcia-Garcia SC, Herz-Ruelas ME, Gomez-Flores M. Association of trichorhinophalangeal syndrome and loose anagen syndrome: a case report. Skin Appendage Disord. 2020;6(3):162-7. DOI: 10.1159/000506524
The article can be purchased
electronic!
PDF format
700 руб
DOI: 10.14489/lcmp.2026.01.pp.036-040
Article type:
Research Article
Make a request