A case of acute erythroid leukemia (AEL) is described in a 75-year-old female patient with cytopenia and bone marrow infiltration with undifferentiated blast cells (?50 %) with decreased bone marrow cellularity. Cytochemical analysis revealed a predominance of a diffusely granular pattern in the periodic acid–Schiff (PAS) reaction, which is atypical for AEL and complicated the cytomorphological diagnosis. The diagnosis was confirmed by immunophenotyping. The case highlights the variability of morphological characteristics in the diagnosis of atypical variants of AEL.
Aleksey I. Makarchev – Physician at the Clinical Diagnostic Laboratory (CDL), Moscow State Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow Healthcare Department; Assistant at the Department of General Pathology, Faculty of Medicine and Biology, Russian National Research Medical University (RNRMU), Moscow, Russia.
Anastasia A. Chekasina – Physician at the Clinical Diagnostic Laboratory (CDL), Moscow State Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow Healthcare Department, Moscow, Russia.
Nikolay I. Stuklov – Hematologist, Doctor of Medical Sciences, Professor, Head of the Hematology Course, Department of Hospital Therapy with Courses in Endocrinology, Hematology and Clinical Laboratory Diagnostics, Medical Institute, Peoples' Friendship University of Russia (RUDN University) named after Patrice Lumumba, Moscow, Russia.
Elena O. Lugovaya – Physician at the Clinical Diagnostic Laboratory (CDL), Moscow State Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow Healthcare Department, Moscow, Russia.
Rinat R. Gimadiev – Physician at the Clinical Diagnostic Laboratory (CDL); Instructional Master at the Department of Hospital Therapy with Courses in Endocrinology, Hematology and Clinical Laboratory Diagnostics, Medical Institute, Peoples' Friendship University of Russia (RUDN University) named after Patrice Lumumba; Assistant at the Department of General Pathology, Faculty of Medicine and Biology, Russian National Research Medical University (RNRMU), Moscow, Russia.
Elena V. Gubina – Student at the Institute of Digital Biodesign and Modeling of Living Systems, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Svetlana V. Chausova – Doctor of Medical Sciences, Associate Professor, Head of the Department of General Pathology, Faculty of Medicine and Biology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia.
Margarita A. Kostina – Physician at the Clinical Diagnostic Laboratory (CDL), Moscow State Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow Healthcare Department, Moscow, Russia.
1. Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17-48. DOI: 10.3322/caac.21763
2. Zuo Z, Polski JM, Kasyan A, et al. Acute erythroid leukemia. Arch Pathol Lab Med. 2010;134(9):1261-70. DOI: 10.5858/2009-0350-RA.1
3. Alaggio R, Amador C, Anagnostopoulos I, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022;36(7):1720-48. DOI: 10.1038/s41375-022-01620-2
4. Reichard KK, Tefferi A, Abdelmagid M, et al. Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases. Blood Cancer J. 2022;12(11):147. DOI: 10.1038/s41408-022-00746-x
5. Wells AW, Bown N, Reid MM, et al. Erythroleukaemia in the north of England: a population based study. J Clin Pathol. 2001;54(8):608-12. DOI: 10.1136/jcp.54.8.608
6. Liu W, Hasserjian RP, Hu Y, et al. Pure erythroid leukemia: a reassessment of the entity using the 2008 World Health Organization classification. Mod Pathol. 2011;24(3):375-83. DOI: 10.1038/modpathol.2010.194
7. Hasserjian RP, Germing U, Malcovati L. Diagnosis and classification of myelodysplastic syndromes. Blood. 2023;142(26):2247-57. DOI: 10.1182/blood.2023020078
8. Polyatskin IL, Artemyeva AS, Krivolapov YA. Peresmotrennaia klassifikatsiia VOZ opukhole? gemopo?tichesko? i limfoidno? tkane?, 2017 (4-e izdanie): opukholi limfoidno? tkani. Arkh Patol. 2019;81(3):59-65. DOI: 10.17116/patol20198103159
9. Dohner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-47. DOI: 10.1182/blood-2016-08-733196
10. Bernard E, Tuechler H, Greenberg PL, et al. Molecular international prognostic scoring system for myelodysplastic syndromes. NEJM Evid. 2022;1(7):EVIDoa2200008. DOI: 10.1056/EVIDoa2200008
11. Gera K, Martir D, Xue W, et al. Survival after pure (acute) erythroid leukemia in the United States: a SEER-based study. Cancers (Basel). 2023;15(15):3941. DOI: 10.3390/cancers15153941
12. Baranova OYu, Shirin AD. A current view on pathogenesis, diagnosis, and treatment of some rare acute leukemia variants. Clinical Oncohematology. 2022;15(4):307–26. DOI: 10.21320/2500-2139-2022-15-4-307-326
13. Alexander C, et al. A history and current understanding of acute erythroid leukemia. Clinical lymphoma, myeloma & leukemia. 2023;23(8):583–8. DOI: 10.1016/j.clml.2023.04.011
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