Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains a widespread disease with a wide range of clinical manifestations, as well as an unpredictable response to treatment. The etiology of CP/CPPS is probably multifactorial,
and confirmation of the role of infection in its development remains a difficult and debatable problem. Application of novel research methods, including mass spectrometry of microbial markers makes it possible to identify and quantify bacteria of various groups, including anaerobes, viruses, fungi, and minimize sampling requirements. The presence of certain microorganisms and an increased total number of them in patients with CP/CPPS, compared with healthy people, indicates a possible association of infection with prostatitis and requires further study of this problem in order to obtain more reliable results.
Aleksei V. Ignatev – postgraduate student of the Department of endoscopic urology of the FNO MI RUDN, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Zieratsho A. Kadyrov – MD, professor, the head of the department of endoscopic urology and ultrasound diagnostic of faculty of continuous medical education of medical institute in ‘Peoples’ Friendship University of Russia’, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Shota V. Ramishvili – postgraduate student of the department of endoscopic urology and ultrasound diagnostic of faculty of continuous medical education of medical institute in ‘Peoples’ Friendship University of Russia’, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Vladimir S. Stepanov – assistant of endoscopic urology and ultrasound guidance department of faculty of postgraduate education of faculty of medical institute in ‘Peoples’ Friendship University of Russia’, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Olga V. Bystrova – Senior Researcher at the Department of Microbial Markers, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
1. Apolihin OI, Komarova VA, Nikushina AA, et al. Prostate diseases in the Russian Federation: statistical data for 2008–2017. Experimental and clinical urology. 2019;2:4-13. (In Russ). DOI: 10.29188/2222-8543-2019-11-2-4-12
2. Pendegast HJ, Leslie SW, Rosario DJ. Chronic Prostatitis and Chronic Pelvic Pain Syndrome in Men. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024.
3. Kadyrov ZA, Stepanov VS, Ramishvili ShV, et al. Diagnostics of chronic nonbacterial prostatitis. Andrology and Genital Surgery. 2019;20(3):36-42. (In Russ). DOI: 10.17650/2070-9781-2019-20-3-36-42
4. Kogan MI, Naboka YL, Ismailov RS. Prostatic secretion microbiota: a comparative analysis of the сhronical prostatitis II and IIIA category. Urologiia. 2020;2:16-22. (In Russ). DOI: 10.18565/urology.2020.2.16-22
5. Magistro G, Wagenlehner FME, Pilatz A. Chronic prostatitis/chronic pelvic pain syndrome. Urologie. 2023;62(6):590-6. DOI: 10.1007/s00120-023-02089-2
6. Kadyrov ZA, Faniev MV, Ramishvili ShV, et al. Microbiota of prostate secretion in patients with chronic abacterial prostatitis. Andrology and Genital Surgery. 2024;25(1):73-86. (In Russ). DOI: 10.62968/2070-9781-2024-25-1-73-86
7. Lobel B, Rodriguez A. Chronic prostatitis: what we know, what we do not know, and what we should do! World J. Urol. 2003;21:57-63. DOI: 10.1007/s00345-003-0336-1
8. Osipov GA, Rodionov GG. Microenvironment in human health and disease by mass spectrometry of microbial markers. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2013;(2):43-53. (In Russ). DOI: 10.25016/2541-7487-2013-0-2-43-53
9. Kogan MI, Ibishev KhS, Naboka YuL, et al. Extended culture study as a keypoint to rethinking antibiotic therapy for chronic bacterial prostatitis. Urologiia. 2023;1:5-11. (In Russ). DOI: 10.18565/urology.2023.1.5-11
10. Magri V, Boltri M, Cai T., et al. Multidisciplinary approach to prostatitis. Arch Ital Urol Androl. 2019;90(4):227-48. DOI: 10.4081/aiua.2018.4.227
11. Bozhedomov VA. Prostatit: old and new. Moskovskiy urolog. 2023;1:12-13. (In Russ).
12. Naber K, Sukhorukova MV. Microbiological Aspects of Chronic Prostatitis. Clinical antimicrobial chemotherapy. 2006;1(5):4-17.
13. Osipov GA, Rodionov GG. Application of the method of mass spectrometry of microbial markers in clinical practice. Poliklinika. Spetsvypusk: Laboratoriya LPU. 2013;2:68-73. Available at: https://www.poliklin.ru/imagearticle/201302_LAB/68-73.pdf. Accessed: 17 May 2024. (In Russ).
14. Osipov GA. Determination of the composition and number of microorganisms of the intestinal wall by chromatography-mass spectrometry of cellular fatty acids. St. Petersburg, 2016. 48 p. Available at: https://propionix.ru/f/osipov_ga_opredeleniye_sostava_i_kolichestva_mikroorganizmov_kishechnoy_stenki_metodom_khromato-mass-spektrometrii_po_kletoc.pdf. Accessed: 17 May 2024. (In Russ).
15. Pochernikov DG, Pustovoitenko NT, Davidova ZhYu. The effectiveness of modification of the preanalytical laboratory stage of PCR in order to identify hidden urogenital infections in men. Laboratory and clinical medicine. Pharmacy. 2023;3(2):4-11. (In Russ). DOI: 10.14489/lcmp.2023.02.pp.004-011
16. Sapozhkova ZhYu, Milovanova GA, Pochernikov DG, et al. Diagnostic capabilities of ejaculate sediment examination with the help of nucleic acid amplification by polymerase chain reaction and microbiologic examination in searching for causes of male reproductive disfunction. Medical Technologies. Assessment and Choice. 2022;44(2):62-71. (In Russ.). DOI: 10.17116/medtech20224402162
17. Davidova ZhYu, Chelikova GA. The role of an interdisciplinary approach in the search for effective diagnostic algorithms in the laboratory examination of patients with diseases of the male accessory gonads. Laboratory and clinical medicine. Pharmacy. 2024;4(1):17-24. (In Russ). DOI: 10.14489/lcmp.2024.01.pp.017-024
18. Osipov GA, Beloborogova NV. Method of detection of pathogen in sterile biological media of microorganism. Patent RUS №2146368. 10.03.2000.
19. Osipov GA, Istratov VG, Shabanova EA, et al. Method of anaerobic mephitic gangrene diagnosis. Patent RUS №2021608. 10.05.1994.
20. Osipov GA. Method of determination of genus species) composition of microorganism assosiation. Patent RUS №2086642. 10.08.1997.
21. Osipov GA. Chromatography-mass spectrometric analysis of microorganisms and communities in clinical samples for infections and dysbiosis. In: Chemical analysis in medical diagnostics. Moscow: Naukapublishers; 2010. P. 293-368. (In Russ).
22. Glukhovets BI, Khodareva AG. Analysis of the microbiocenosis of the reproductive system by chromatography-mass spectrometry: a practical guide. St. Petersburg, 2016. 61 p. (In Russ).
23. Pisanov RV, Shipko ES, Duvanova OV, et al. Identification of microorganisms using gas chromatography-mass spectrometry. Journal of Microbiology, Epidemiology and Immunobiology. 2020;97(4):356-62. (In Russ). DOI: 10.36233/0372-9311-2020-97-4-8
24. Kuz'min MD. Chronic abacterial prostatitis. A new approach to understanding pathogenesis and treatment. Moskovskiy urolog. 2023;1:6-7. (In Russ).
25. Song W, Gao J, Huang J, et al. Is type III prostatitis also associated with bacterial infection? Front Cell Infec Microbiol. 2023;13:1189081. DOI: 10.3389/fcimb.2023.1189081
26. Fedorova EP, Osipov GA, Istomin OA, et al. Establishment of the expanded composition of the microbial community of the endometrium in pathologies and the importance of data in the practice of an obstetrician-gynecologist. Polyclinic. 2021;3:34-39.
27. Gostry AV, Simonova AV, Mikhailova NA, et al. Chronic pharyngitis: etiology, pathogenesis, treatment. New approaches to the estimation of etiopatogenesis. The Russian Archives of Internal Medicine. 2019;9(1):32-43. DOI: 10.20514/2226-6704-2019-9-1-32-43
28. Zhukov VA. Violation of the intestinal microbiota and its correction in patients with uncomplicated urinary tract infection. [dissertation]. M., 2023. 133 p. Available at: https://www.rudn.ru/storage/media/science_dissertation/de1323a7-eabd-43b7-a28d4e2a0aa573d7/cD8Nwqw1tlicUotNp10rv9uJxHAefa5wNBduUCa2.pdf. Accessed: 17 May 2024. (In Russ).
29. Kadyrov ZA, Stepanov VN, Faniev MV, et al. Microbiota of the urogenital organs. Urologiia. 2020;1:116-20. (In Russ). DOI: 10.18565/urology.2020.1.116-120
30. Zakharova IN. Microbiome, microbiota. What's new? Medical Council. 2016;16:92-97. (In Russ). DOI: 10.21518/2079-701X-2016-16-92-97
31. Wu Y, Jiang H, Tan M, et al. Screening for chronic prostatitis pathogens using high-throughput next-generation sequencing. Arch Ital Urol Androl. 2020;80(7):577-587.
32. Magistro G, Marcon J, Eismann L, et al. The role of the microbiome in urology. Urologia. 2020;59(12):1463-71. DOI: 10.1007/s00120-020-01368-6
33. Atzler M, Westhofen T, Tamalunas A, et al. The role of the microbiome in urological diseases. Aktuelle Urol. 2021;52(4):338-44. DOI: 10.1055/a-1478-2960
34. Moustafa A, Li W, Singh H, et al. Microbial metagenome of urinary tract infection. Sci Rep. 2018;8(1):4333. DOI: 10.1038/s41598-018-22660-8
35. Sturov NV, Popov SV, Mikhailov AA, et al. Disturbance of the gut microbiota and its correction in patients with chronic prostatitis. Farmateka. 2024;1:208-13. (In Russ). DOI: 10.18565/pharmateca.2024.1.208-213
36. Miyake M, Tatsumi Y, Ohnishi K, et al. Prostate diseases and microbiome in the prostate, gut, and urine. Prostate Int. 2022;10(2):96-107. DOI: 10.1016/j.prnil.2022.03.004
37. Wang S, Zang M, Yang X, et al. Gut microbiome in men with chronic prostatitis/chronic pelvic pain syndrome: profiling and its predictive significance. World J Urol. 2023;41(11):3019-3026. DOI: 10.1007/s00345-023-04587-6
The article can be purchased
electronic!
PDF format
700
DOI: 10.14489/lcmp.2024.03.pp.048-057
Article type:
Review
Make a request
